Thursday, October 31, 2024 11:40am to 1:15pm
About this Event
Biomedical Sciences Building Red Hill Road, Santa Cruz, California 95064
Presenter: Andy Yeh
Description: Bioluminescence technology provides highly sensitive and non-invasive imaging in living organisms without external excitation. However, the capabilities of naturally occurring luciferases, the enzymes that catalyze light emission, have limited the full potential of luminescence technology for the past several decades. We overcome these natural limitations by developing a new generation of luciferases through AI-powered de novo protein design, enhancing the performance beyond that of native luciferases. Our artificially designed luciferase catalysts facilitate genetic labeling at molecular, cellular, and individual levels, allowing for multiplexed applications.
Bio:Dr. Yeh earned his PhD in Chemistry from the University of Virginia before joining the Institute for Protein Design at the University of Washington, where he focused on designing new protein switches and enzymes from scratch. His lab utilizes deep learning-based protein design and prediction algorithms to develop artificial light-emitting systems that can be genetically encoded within biological systems. Such technology can be used to study complex biological phenomena at various scales and to enable highly sensitive assays for diagnostics.
Hosted by: Professor Nader Pourmand & UC Santa Cruz BME Department
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